Kyrgios spent most of the match complaining of being blinded by the lights on Arthur Ashe Stadium.
He needed eye drops from the tournament physio just three games in.
"I throw the ball up in the air and I can't see for,like,30 seconds after,"he said,adding that he was guessing where the next ball was going to be when he tried to hit it.
But there was bigger trouble shortly after when a linesman reported Kyrgios for allegedly swearing.
The 28th seed wasn't happy during a talking-to from the chair umpire,yelling at the linesman from his changeover chair:"whistleblower"before demanding Eva Asderaki to"get him off".
"I said I can't see a thing. That's all I said,"Kyrgios claimed.