Carlton spearheads Harry McKay and Charlie Curnow booted three goals apiece,while Sam Walsh tallied 23 disposals in the first half alone before finishing with 32 possessions.
Blues captain Patrick Cripps was dominant with 29 disposals and a game-high 10 clearances.
Former Dockers duo Adam Cerra (27 disposals,six clearances,one goal) and Blake Acres (23 disposals,four clearances) both played important roles to rub further salt into the wound for Fremantle.
The triumph lifted Carlton from 15th to 11th on the ladder,with the Blues now just one win adrift of eighth spot ahead of a big challenge against Port Adelaide at Marvel Stadium next weekend.
But Sunday’s win came at a cost,with Matthew Kennedy carried off by two trainers in the third quarter after injuring his right knee in a tackle.
Defender Mitch McGovern suffered a game-ending left thigh injury just before three-quarter time after a collision in a marking contest.