Joe Ingles made two pivotal three-pointers in the final quarter,while Ben Simmons was just two rebounds shy of a triple-double.
The last remaining unbeaten home record this NBA season is over after the Philadelphia 76ers lost 108-104 to eastern conference rivals Miami.
The Brooklyn Nets have capitalised on Joel Embiid's absence to beat the Ben Simmons-led Philadelphia 76ers by 20 points.
Joel Embiid scored a season-high 38 points and added 13 rebounds as Philadelphia handed Boston their first home loss on Thursday night (local time).
The Philadelphia 76ers have extended their perfect home record this season to 13 wins with a hard-fought 97-92 defeat of the Denver Nuggets.
With Joel Embiid and Ben Simmons slightly subdued it was up to Philadelphia's other NBA gun,Tobias Harris,to fire them past Utah 103-94 with 26 points and nine rebounds.
Ben Simmons showed his defensive game continues to flourish,coming up with three crucial steals as the Sixers held off Indiana in Philadelphia on Sunday.
Joel Embiid rebounded from the worst game of his career with 33 points and 16 rebounds to lead Philadelphia 76ers to a 97-91 victory over Sacramento Kings.
Philadelphia 76ers superstar Joel Embiid has failed to score a point as defending NBA champions Toronto extended their hoodoo over the visitors with a 101-96 victory.
Ben Simmons scored 18 points to go with eight rebounds and five assists but the Philadelphia 76ers,playing without Joel Embiid,lost to Orlando.
The Australian star showed no ill-effects on his return from the shoulder strain that sidelined him for two games as Philadelphia beat Cleveland 98-97.