Pope Francis denounced the violence as an assault on democracy.
The agency monitors financial transactions to identify money laundering,organised crime,tax evasion,welfare fraud and terrorism financing.
The main target is the Secretariat of State,the most important part of the Vatican administration,which must relinquish management of its funds.
Pope Francis also appeared to criticise people who have refused to wear masks because it violates their freedom,an attitude that has become widespread in nations such as the US.
"The Son of God was born an outcast,in order to tell us that every outcast is a child of God,"Pope Francis said.
As two cardinals test positive to coronavirus and Italy's lockdown hits the Christmas message,the Vatican says the vaccine is"morally acceptable".
Pope Francis also said the holy day that marks the birth of Jesus had been"kidnapped"by consumerism.
Francis had hoped to make a trip this year but his plans were scuppered first by security concerns and then by the coronavirus pandemic.
Three Aboriginal men are seeking punitive damages against Pope Francis for the church's failure to protect them from notorious paedophile priest Michael Glennon.
The Pope praised those who protested against the death of George Floyd in police custody for rallying around the"healthy indignation"that united them.
Catholic social justice teaching that “we are all in the same boat” holds potential for a new sort of moment in the Democratic Party,the church and the US.