Donald Trump has jettisoned international negotiations that were crucial to making Silicon Valley firms pay more tax in Australia.
"Over-dependence on other countries as a source of cheap medical products and supplies has created a strategic vulnerability to our economy,"Robert Lighthizer said.
Trade Minister Simon Birmingham has warned the erosion of the WTO's dispute-settlement function takes the world closer to a"might is right"trade system.
US trade representative Robert Lighthizer says the deal has been done but its success will be up to decisions by officials in Beijing.