About 7.30pm,a Ford Falcon sedan was driving on Bussell Highway when it crossed onto the wrong side of the road and into the path of a semi-trailer.
Authorities have closed the Great Northern Highway between Doon Doon and the Victoria Highway while emergency services are on site.
The deaths come after WA police launched a traffic campaign focused on driving during the festive season earlier this month.
A bushfire on the edge of the Kwinana Freeway has backed up traffic southbound with weekend motorists advised to avoid an affected area near Mt Henry Bridge and Aquinas College.
Rescue workers had to cut three passengers from their mini-van after it crashed in to a tree on the outskirts of Kalgoorlie on Friday evening.
Since arriving earlier this year,the industry has had a faster uptake in Perth than any other Australian city,with one in three new users offering up their cars identifying as shift workers.
WA is the worst performing state with annual road deaths per 100,000 people sitting at 6.38,behind the Northern Territory’s 15 deaths.
The court heard De Pledge had been driving a truck carrying 180 cattle from Hooley Station to Broome when he failed to adequately slow down for roadworks and hit the caravan.
Great Northern Highway has been closed from Rutland Road to Brand Highway after a car and truck collided just after 8am.
As the car sharing economy gains momentum in Australia,with more people choosing to get rid of their cars to embrace a more flexible lifestyle,Perth could become the perfect location to develop the industry.
Police were called to three separate crashes throughout the Perth region on Friday evening.