An official with knowledge of the case said the woman had received the AstraZeneca vaccine.

NSW Premier Gladys Berejiklian told Nine’sToday show on Friday she did not know if the death was linked to the vaccine.

“I know as much as you do,” she said. “All I do know is that the federal authorities are looking into these matters to see if there is that link. In the meantime,we just extend our heartfelt condolences to the family and loved ones during this difficult time.

“We’re waiting for the federal authorities to let us know whether there is a link and,until that time,I think we should just wait for that advice.”

The 48-year-old woman from the NSW Central Coast was given a vaccine on Friday and developed major blood clots the next day and was put on dialysis,theDaily Mailreported,adding that she was diabetic but otherwise in good health.

A link between a vaccine and the woman’s blood clots has not been confirmed by health authorities.

Diabetes can significantly increase the risk of some types of blood clots.

The federal government last week updated its advice to make the Pfizer vaccine the preferred treatment for Australians under 50.

But authorities have maintained the vaccine remains safe,with side effects extremely rare.

There have been two previously confirmed cases in Australia of a rare but serious blood clotting disorder linked to the AstraZeneca vaccine.

Thefirst confirmed case was a 44-year-old Victorian man,while the second was a woman in her 40s from Western Australia who had received the vaccine in mid-March.

The blood clotting disorders being investigated in connection with the AstraZeneca vaccine are very rare and differ from common blood clots,which occur in about 50 Australians every day.

“The TGA is responsible for regulating and monitoring the use of COVID-19 vaccines in Australia. Monitoring involves detecting and responding to any emerging safety concerns related to COVID-19 vaccines,particularly any adverse events following immunisation,” a NSW Health statement said.

“NSW Health is notified when a serious or unexpected adverse event occurs. NSW Health investigates these events and refers its expert panel findings to the TGA,which is responsible for assessing causality.

“Many conditions can arise during normal life,whether or not a vaccine is administered,but it remains important to report any new serious or unexpected events so that safety can be appropriately monitored.”

with AAP